Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome
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چکیده
منابع مشابه
Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome.
Inflammasomes are cytosolic multiprotein complexes that initiate host defense against bacterial pathogens by activating caspase-1-dependent cytokine secretion and cell death. In mice, specific nucleotide-binding domain, leucine-rich repeat-containing family, apoptosis inhibitory proteins (NAIPs) activate the nucleotide-binding domain, leucine-rich repeat-containing family, CARD domain-containin...
متن کاملHuman NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation.
Inflammasome mediated by central nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) protein is critical for defense against bacterial infection. Here we show that type III secretion system (T3SS) needle proteins from several bacterial pathogens, including Salmonella typhimurium, enterohemorrhagic Escherichia coli, Shigella flexneri, and Burkholderia spp., can induce robust ...
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چکیده ندارد.
A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system.
Bacterial pathogens utilize pore-forming toxins or specialized secretion systems to deliver virulence factors to modulate host cell physiology and promote bacterial replication. Detection of these secretion systems or toxins, or their activities, by nucleotide-binding oligomerization domain leucine-rich repeat proteins (NLRs) triggers the assembly of inflammasomes, multiprotein complexes necess...
متن کاملTracking the Bacterial Type III Secretion System: Visualization of Effector Delivery Using Split Fluorescent Proteins.
Bacterial pathogens use the Type III secretion system to deliver dozens of effector proteins into host cells; for example, the plant pathogen Pseudomonas syringae can deliver more than 30 effectors. These effectors have multiple, nefarious functions that help the pathogen thrive in its host (reviewed in Toraño et al., 2016). Effectors target conserved host processes including pathways for entry...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1710433114